Mannose

Nature is the best. I said.

"In summary, we demonstrate that mannose directly targets PKM2 in bladder cancer cells, suppressing its enzymatic activity and inhibiting glycolysis and lactate production. This metabolic reprogramming leads to suppression of PKM2 lactylation while promoting its nuclear translocation. Nuclear-localized PKM2 subsequently activates the NF-κB inflammatory signaling pathway, inducing pyroptosis-mediated tumor suppression and fostering an antitumor immune microenvironment."

Jin, H., Wu, P., Lv, C. et al. Mannose inhibits PKM2 lactylation to induce pyroptosis in bladder cancer and activate antitumor immune responses. Commun Biol 8, 689 (2025). 
https://doi.org/10.1038/s42003-025-08130-8

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