on the way: 2025.10

2025年10月31日星期五

2025年10月30日星期四

"In summary, we demonstrate that mannose directly targets PKM2 in bladder cancer cells, suppressing its enzymatic activity and inhibiting glycolysis and lactate production. This metabolic reprogramming leads to suppression of PKM2 lactylation while promoting its nuclear translocation. Nuclear-localized PKM2 subsequently activates the NF-κB inflammatory signaling pathway, inducing pyroptosis-mediated tumor suppression and fostering an antitumor immune microenvironment."

Jin, H., Wu, P., Lv, C. et al. Mannose inhibits PKM2 lactylation to induce pyroptosis in bladder cancer and activate antitumor immune responses. Commun Biol 8, 689 (2025).
https://doi.org/10.1038/s42003-025-08130-8

https://www.facebook.com/groups/1328998247989889/

2025年10月29日星期三

Slow

There are many things happening everyday. Days should be busy meaningfully. Why do my counterparts keep working in slow motion? Teruklah...

2025年10月28日星期二

Alpha and Omega

I broke a sink pipe this evening. This is the third thing in 12 days. The first two cases happened on the 17th and 25th. When I just came back here, I was always breaking things too. Maybe three to four water-taps at least. Of course those water-taps were in bad condition already. I was "lucky" enough to have them retired in my hands. People saw me as a destroyer, but I saw myself as a quality tester - only good things could last and survive with me. Now seems like a similar period. Is this a type of Alpha and Omega?

2025年10月27日星期一

Red beans

2025年10月26日星期日

MO

Morning fried beehoon

that supports whole day work

Out of the shield, for you are able to shine

SLEEP!

2025年10月25日星期六

Behave yourself

2025年10月24日星期五

大食

I need foods

https://www.theworldofchinese.com/2011/01/on-the-character-%E9%A3%9F/

It's raining outside. Nice. Sweet rest.

2025年10月23日星期四

Double Perfection

So, confirm there are two seven petals rain lily flowers.

Planted two pairs of pineapples that have roots grown as they were put in water for quite a long time. I hope them grow their roots deeply into the soil as the first step of development.

Collected 8 sugar apples, 11 sesame fruit capsules and 1 papaya.

Long internet cables and a wardrobe size block have been set up at the junction. So, that's the village level data centre.

Work real. Thank you.

2025年10月22日星期三

IWTBW

It's not a so-good day heading forward to me today, who knows.

Working hard does not equal either good results or reviews.

They look the same. I am also not very sure if they are the same. If yes, then perfectness appears in a slightly different outlook sometimes. If not, then all the different perfectness have similar elements inside.

Being courageous, honest and responsible are among the important values of a leader that I would respect. There may not be severe incidents to be happened and faced, but a leader should have these values to assure the organisation, whether it is small or big.

World Happiness Report 2025

https://www.worldhappiness.report/

https://www.gallup.com/analytics/349487/world-happiness-report.aspx

https://www.vogue.fr/article/cultiver-le-bonheur-conseils-finlandais

2025年10月21日星期二

光明正大

Light is bright

Righteous is great

No worries

No fear

For there will be response

Thank you

2025年10月20日星期一

Thank you for your notice

You must do it

I look forward to it

Good sleep

2025年10月19日星期日

Macam manaleh...

No talk, no ask

Move here, move there

When spotted, run away

But too fat, got stucked

But too slow, got caught

Teruklah, macam manaleh...

2025年10月18日星期六

Good indeed

A sesame tree knows what to do

Good indeed

Learn from it, please

Thank you

Salute

Salute to real act, real bloom, real presence

For your sake in long-term

Please

Thank you

2025年10月17日星期五

IAJI

It's fine if you're not so pretty

As long as you're example-being

Jangan main-main

I need a rainy night

Good rest

Thank you

2025年10月16日星期四

Step out of comfort zone

Make sure you learn new things and practice them to have a wonderful real life journey and results. Don't sit back to fail yourself. Thank you.

2025年10月15日星期三

Who knows

It's a shining day that who knows I am going to have an adventurous driving journey without internet connection.

2025年10月14日星期二

Busy gila

2025年10月13日星期一

You first

Much appreciated

SLEEP

2025年10月12日星期日

Write or call

C, my undergraduate student years ago, sends me postcards periodically. This afternoon I received a meeting invitation message from a Tianjin-originated Australian friend who married a Taiwanese, as she is going to KL coming weekend. I replied to her that I am away from KL now so I can't make it. Replying is basic etiquette. Some friends call sometimes. All these are so precious. I treasure those people whom I can write to or call to whenever I wish to do so. I feel more blessed when I get replies from them.

SLEEP

THANK YOU

2025年10月11日星期六

Y7SN

You first

700g tapioca

Strong man

Nice evening

M asks me to reschedule the class for certain reason. A good 17 years old student knows how to do things well.

Do real work

Have nice sleep

Thank you

2025年10月10日星期五

3-0✌

A mature sesame fruit is brown in colour.

Never imagine that I would have a chance to grow a sesame tree until have the seeds! It's a gift sent from above because I didn't plant it. Sesame seed is like mustard seed. Through agriculture you know the Creator.