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Good rest

Mannose

Nature is the best. I said.

"In summary, we demonstrate that mannose directly targets PKM2 in bladder cancer cells, suppressing its enzymatic activity and inhibiting glycolysis and lactate production. This metabolic reprogramming leads to suppression of PKM2 lactylation while promoting its nuclear translocation. Nuclear-localized PKM2 subsequently activates the NF-κB inflammatory signaling pathway, inducing pyroptosis-mediated tumor suppression and fostering an antitumor immune microenvironment."

Jin, H., Wu, P., Lv, C. et al. Mannose inhibits PKM2 lactylation to induce pyroptosis in bladder cancer and activate antitumor immune responses. Commun Biol 8, 689 (2025). 
https://doi.org/10.1038/s42003-025-08130-8

https://www.facebook.com/groups/1328998247989889/

Slow

There are many things happening everyday. Days should be busy meaningfully. Why do my counterparts keep working in slow motion? Teruklah...

Alpha and Omega

I broke a sink pipe this evening. This is the third thing in 12 days. The first two cases happened on the 17th and 25th. When I just came back here, I was always breaking things too. Maybe three to four water-taps at least. Of course those water-taps were in bad condition already. I was "lucky" enough to have them retired in my hands. People saw me as a destroyer, but I saw myself as a quality tester - only good things could last and survive with me. Now seems like a similar period. Is this a type of Alpha and Omega?